Omeprazole: Contraindications, Side Effects, Benefits, Etc.

This drug omeprazole is well known to treat issues related to the digestive system, it has derivatives such as pantoprazole, lansoprazole and esomeprazole. Capable of helping to favorably reduce the increase in gastric acid emanating from the glands present around the stomach.

This type of drug, such as omeprazole, is prescribed on a regular basis to calm the discomfort of gastric reflux and also to stop stomach or duodenal ulcer-type discomfort . These drugs are also known as a proton pump , capable of minimizing these annoying symptoms when acid or gastric juices are increased-

This drug was created by the Swedish laboratories Aktiebolaget Hassle, in the 1980s , when omeprazole was registered, information verified by the World Health Organization.

Some time after this important event, the protection of this medicine was defeated , which is of great importance to level the production of gastric acid, since then its production for commercial purposes began, being then a generic medicine.

It is one of the few existing drugs that do not generate adverse effects unlike others. Save yourself some symptoms that until now are very occasional such as dizziness, constipation, nausea or headache. That is why we will introduce you to the most basic of this drug below.

What is omeprazole?

Omeprazole is generally characterized as a drug indicated to treat digestive system issues , especially to minimize conditions such as heartburn. It is a common discomfort in many people, and is often confused with antacids .

In this order of ideas we have antacids, they are drugs that act as reducers of acidity in the stomach that can be occasional and immediately. In this way, Omeprazole is used in the patient for medium periods or also for long term, giving its effectiveness a few days after starting the treatment.

Omeprazole characteristics

Omeprazole is a drug derived from benzylimidazole represented, which is also highly effective since it operates selectively against gastric acid mucus, in a basal and also stimulated manner, proven in man and in animals.

Omeprazole is the main existing module, of many that have been generated from it in order to exert functions to calm ulcers, thus reducing the production of acids , which is clearly the inhibition of enzymes such as potassium adenosine triphosphatase, hydrogen, or (H + / K +) gastric ATPase, which is a gastric parietal or oxyntic, proton pump reducing enzyme; It is important to mention that it works only on the gastric enzyme.

It is important that the performance of the proton pump originates at the end, which is something frequent in relation to these gastric secretory processes , from this way it is deduced that omeprazole is capable of considerably lowering the production of intragastric acidity, regardless of where the nature of the main stimulus.

By reducing gastric acidity, it is a good sign of the effectiveness of anti-ulcer medications, and omeprazole is among this group of drugs that provides good results in this matter.

Omeprazole is a white, transparent powder that melts at 155ºC with disintegration, usually with a brittle basic appearance, but that can be soluble in methanol, in lipids, and in ethanol, in the same way it is subtly soluble before isopropanol or acetone , but it is also remarkable that it is poorly soluble in water . The stability of the substance is very important for the pH function: which degrades rapidly in the presence of acid, however it continues to protect alkaline conditions without any alteration.

Omeprazole scientific name

The scientific name of omeprazole is expressed as follows:

5-Methoxy-2 – [[(4-methoxy-3,5-dimethyl-2-pyridinyl) methyl] sulfinyl] benzimidazole

What is the pharmacological group of omeprazole?

This medicine called omeprazole belongs to a group of proton pump inhibitors. What causes it to be a fragile platform capable of compressing gastric acid mucus through a very selective mode of operation. This determined inhibitor of the proton pump in the gastric parietal cell. It also works by causing control through variant inhibition of stomach acid secretion.

Recommended dose of omeprazole

  • It is advisable to ingest omeprazole on an empty stomach, it is the best time of day since the stomach has not received food and the parietal cells deploy more proton pumps at rest.
  • The amount of medicine the body receives varies according to the patient’s illness. We show you some examples:
  • Treatment of persistent or recurrent heartburn (off label): take 1 tablet of 20 mg daily for a period of 14 days.
  • Duodenal ulcer : the dose for this pathology is 1 tablet of 20 mg daily for a period of 4 weeks. If symptoms persist, continue for 8 weeks.
  • Gastroesophageal reflux : the dose corresponds to 1 tablet of 20 mg daily for 4 weeks.
  • Gastric ulcer: for a gastric ulcer, treatment consists of 1 tablet of 20 mg daily for a period of 4 to 8 weeks. If there are ulcers larger than 1 cm, it is increased to 40 mg per day for 8 weeks.
  • Zollinger-Ellison syndrome: corresponds to 60 mg per day or is adjusted to 120 mg per day distributed in daily doses. And persist with it until the symptoms improve.
  • Erosive esophagitis: corresponds to 1 tablet of 20 mg daily for a period of 4 to 8 weeks. If symptoms continue, it lasts up to 12 weeks.
  • Treatment of duodenal or gastric ulcer induced by anti-inflammatory drugs: take 1 tablet of 20 mg daily for a period of 4 to 8 weeks.
  • Treatment of anti-inflammatory induced gastric or duodenal ulcer: take 1 tablet of 20 mg daily for up to 6 months.

In the event that the person is having difficulty ingesting the tablets, they can be dissolved in a little water and swallowed at once.

Active ingredients of omeprazole

Its active ingredient is its name Omeprazole.

Pharmacokinetics and Pharmacodynamics of Omeprazole

This medication OMEPRAZOLE is determined an antisecretory and an antiulcer , for which it acts as a specific inhibitor of the hydrogen pump present in the gastric parietal cell. Therefore, it represents a weak platform that clusters, changing to the active form under an extremely acidic state of the intracellular canaliculi of the parietal cell, thus preventing the passage of the enzyme H + – K + -ATPase, which is the pump of protons.

It would already be the culmination of the gastric acid formation course, which is a dependent dose, which in turn corresponds to a highly powerful inhibition, pertaining to basal acid secretion as well as acid secretion freely caused by the stimulus.

When determining the type of condition, your doctor prescribes the dose corresponding to 20 mg of omeprazole daily, preferably on an empty stomach to take advantage of the safe inhibition of gastric acid secretion during the day and at night, in this way, greater results are obtained during the first four days started. medication.

The drug omeprazole is devoid of acidic pH , which is why the dose is distributed in tiny granules wrapped in a capsule. To facilitate greater absorption that usually takes place in the small intestine, in an effective period of approximately 3 to 6 hours. In this order of ideas, the continuity of the oral dose is determined by 35%, thus increasing to 60% after the first intake of the one repeated once a day.

Taking omeprazole with food does not cause any problems with bioavailability. This is why the binding with plasma proteins is carried out in 95%. Similarly, it is fully metabolized in organs such as the liver, it should be noted that it is the primary metabolite – hydroxyomeprazole in plasma .

In this way, no metabolites towards gastric secretion have been determined . Another very important thing is when leaving the body it does so by means of 80% when urinating and the remaining 20% through the feces .

What is omeprazole for?

This drug called omeprazole is fully adapted to combat health conditions such as gastritis , as well as gastric ulcer by effectively compressing the heartburn. Another very common use of omeprazole is reflected in preserving the stomach mucosa once anti-inflammatory drugs have been ingested in a period greater than 3 days.

In general, the use of omeprazole is used to treat diseases of the digestive system such as heartburn, duodenal ulcer, reflux esophagitis , stomach ulcer, gastritis, Zollinger-Ellison syndrome , H. pylori Likewise, there are some patients who do not improve with other medications.

Another way to contribute to the healing of digestive diseases is the use of omeprazole as a gastric protector, due to its great effectiveness in preserving the stomach walls, facing common symptoms that act as a side effect of other medicines that have been ingested for long periods Such is the case of anti-inflammatory treatments.

How to take omeprazole?

The dose of omeprazole corresponds mainly in the morning, or the times indicated by your doctor, increasing the ability to combat internal stomach pain, and to exert protection to the stomach lining.

  • Primordial to eat on an empty stomach , swallowing directly, do not think about it, chew.
  • Respect the established schedule for medicine, thus greater effectiveness is achieved .
  • If required, 80 mg or more can be taken in several doses per day .
  • There is a presentation for injection in the form of lyophilized powder which must be supplied by someone specialized.
  • Its presentations are various and are based on intravenous injectable solution, in tablets or tablets and capsules.

Omeprazole benefits and properties

Used against gastritis

For gastritis, you must buy omeprazole with the prescription given by your doctor, this medicine will help you relieve discomfort of gastroesophageal reflux , a digestive condition that is based on delaying the flow of gastric contents of the stomach, this generates the so-called heartburn It can also cause a possible injury to the esophagus.

This medicine is very useful since it acts as a healing of the esophagus , as well as prevents the appearance of other esophageal damage. In the same way, it helps to reduce the production of stomach acids, in the event that a lot of acid is generated, we are in the presence of Zollinger-Ellison syndrome.

In this same vein, a prescription is required to buy omeprazole in case of having lesions in the lining of the stomach or intestine, which are commonly called ulcers, it should be noted that many of these ulcers are caused by type H bacteria . pylori . In the case of heartburn, a doctor’s prescription is not needed since it is a discomfort that manifests itself approximately twice a week.

Continuing with this topic we have that omeprazole is used, when the application of antibiotics clarithromycin and amoxicillin is required , or in that case if sensitivity towards penicillin is present, metronidazole is used, as long as it is to combat and eliminate bacteria such as Helicobacter pylori .1 , H. pylori infections, which in general are the main cause of ulcers, in the digestive tract .

Omeprazole is generally easily absorbed , taking place effectively in the small intestine, depending on the dose administered, for example, when the volume of distribution is less: 0.3 L / kg. And the bioavailability is between 30 and 70%. It is retained for about 30 or 90 minutes in the body, it is discharged via the kidney in 80 percent in the urine and the rest through the fecal matter.

Omeprazole during pregnancy and its effects

It is common for a pregnant woman to experience the symptoms of gastroesophageal reflux, mostly during the first trimester, for this condition omeprazole is used as proton pump inhibitors (PPIs), thanks to its rapid efficiency.

There is a high number of possibilities that it can be bought without a prescription , so it is concluded that there are also a greater number of women in condition, and the sale of this drug is increasing more and more.

It is a safe drug to ingest during pregnancy , according to safety studies of PPIs practiced in animals, no teratogenic effects were reflected, so the US Food and Drug Administration presented omeprazole as a safe drug in pregnancy and they placed it in category C , since at the time of the studies they observed some toxic effects with respect to the embryos and fetuses of the animals at the time they were given high doses.

The aforementioned is related to the studies carried out in animals in which an alarm towards the fetus was determined , in humans it has not been determined there are no studies regarding this.

Currently, a meta-analysis of 7 studies carried out on 1,530 women deployed to PPIs was carried out, the results indicated that during the first trimester they did not present a demonstrative incidence that causes any risk of congenital defects.

Omeprazole during breastfeeding

It is always recommended to consult your doctor to avoid self-medication, however, so far it has not been proven that it affects the child in lactation .

Why take omeprazole before and after eating?

The efficacy of omeprazole occurs mostly on an empty stomach, which means that when you get up you must take it at least 30 minutes before eating any food. In this way the absorption is much more effective to carry out the process of healing and reducing stomach upset in general.

It is not recommended to take medicine just before eating, since it requires a reasonable time to be absorbed by the body , especially in the stomach walls where it is most needed.

If the daily dose is more than one, you should take great caution and take the medication at least 30 minutes before consuming any food in order to help its effectiveness.

Is omeprazole good for children?

There are children who suffer from symptoms such as heartburn and gastric reflux in the upper area of ​​the stomach or esophagus , in this case you can take omeprazole, first determining that the child is allergic to the elements that compose it, as well as being clear that it is not present some liver disease, if these cases occur you can not take omeprazole as it would generate accumulation of its components in the body and aggravate the discomfort already felt or create other unfavorable ones.

Administration to children is done if the pediatrician assigns it in a medical prescription, and following the recommendations exactly as indicated so that there is no problem. Although omeprazole is considered a harmless medicine for infants, however, it is not necessary to self-medicate more if it is in children.

It is very important to fully comply with the scheduled time, with enough water so that it arrives where it belongs.

What is the pediatric dose?

Children and adolescents ≤ 16 years:

To treat gastroesophageal reflux, esophagitis, or gastric and duodenal ulcers, the dose is adjusted according to body weight:

  • From 5 to <10 Kg: corresponds to 5 mg once a day
  • From 10 to ≤ 20 Kg: administer 10 mg daily.
  • > 20 Kg: give 20 mg once a day

Omeprazole and diabetes

There are some prescription drugs to improve peptic ulcers or gastric reflux, which can also act as blockers for the body to properly absorb vitamin B12 . In this case we refer to some proton pump inhibitors such as omeprazole and lansoprazole respectively.

Omeprazole and alcohol

In general, the interaction of drugs with alcohol consumption is not well received by the body, in the case of Omeprazole, which works to inhibit the secretion of acid in the stomach , it is not affected by alcohol consumption, but if it increases heartburn, as well as gastroesophageal reflux, that is why the effectiveness of omeprazole is very low when linked with alcohol.

Is omeprazole abortifacient? Why?

There are no scientific studies that prove its negative effectiveness towards the fetus, therefore it is not considered a product that threatens the possibility of abortion , we know that omeprazole works as a proton pump inhibitor antacid .

Can omeprazole cause cancer?

It has been determined by researchers at University College London, that the excessive and prolonged use of omeprazole affects the risk of stomach cancer since it is a product that acts as proton pump inhibitors (PPIs), which by it is generally used to improve conditions of the digestive system.

On the other hand, having suffered from the bacterium helicobacter pylori , and although it has already been eradicated from the body, you can run the risk of suffering from stomach cancer, remember that this bacterium is responsible for causing sores or ulcers in the stomach and that many times they do not heal in their entirety.

This information was provided by scientists based on various clinical studies carried out to conjugate the use of PPIs, in relation to other types of drug used to oppress acid production , these are called histamine H2 receptor antagonists or H2 blockers, the The study consisted of 63,397 adults who underwent triple therapy: which is a mixture of a PPI with two antibiotics to permanently eliminate the H.pylori bacteria , in a period of 7 days.

After this study, these patients were followed for seven and a half years and most developed this terrible disease of stomach cancer, some died or concluded the study in December 2015 . In this study period, 3,271 of the people represented by 5% ingested PPIs for 3 years and 21,729 took H2 blockers.

Subsequently 153 represented in 0.24% of the people developed stomach cancer after this type of triple therapies, in that study they managed to kill the H.pylori bacteria , it should be noted that all suffered from gastritis for a long time. Therefore, taking PPIs reproduced the possibility of stomach cancer, unlike those who took H2 blockers, they did not present a high risk of it.

In this order of ideas, it was determined by the researchers that consuming proton pump inhibitors daily has a greater incidence, that is, 4 times more likely to have a risk of stomach cancer, even more than taking it weekly.

It was also observed that those who took this drug more than a year daily have 5 times more possibility, and those who take more than two years with daily take represent an 8 times risk of being prone to this disease of stomach cancer.

Is omeprazole considered an antacid?

It is not directly an antacid remedy but it is a controller of the level of gastric acid production. However, its components are capable of counteracting acidity. Omeprazole is a gastric protector to avoid the side effects caused by the consumption of other medications.

In general terms, omeprazole can be taken to prevent and heal ulcers due to excessive acid production, as a result of taking other medications or for stomach issues . It should be taken at the time you feel heartburn discomfort.

Omeprazole vs ranitidine

Among the pharmacotherapy related to bleeding peptic ulcer, it is administered to renew and safeguard the bleeding center, taking care of gastric pH so that it remains above the proteolytic range of pepsin.

It should be noted that this condition must be achieved through the use of acid secretion inhibitors such as proton pump inhibitors or with H2 antagonists. Artal et al carried out an assessment of the antisecretory activity of omeprazole IV (bolus 40 mg every 8 to 12 hours, or continuous infusion 3.3 mg / h) in contrast to IV ranitidine (bolus 50 mg every 4 hours, or infusion of 12.5 mg / h) applied to patients with bleeding duodenal ulcers, to which they determined that the moderations of IV omeprazole were greater than those of ranitidine to increase the pH within 24 hours , in the same way to preserve a pH intragastric higher than the proteolytic range for pepsin in such patients.

Omeprazole is supposed to be a useful drug in faster healing of peptic ulcer . It is for this reason that among the type of H2-antagonists, no clinical variation is determined in efficacy towards various agents, and in relation to the capacity of gastric acid registration , the proton pump inhibitors are better.

In general, omeprazole has always been characterized by being more effective than ranitidine and cimetidine, with respect to the healing procedure of duodenal ulcer, as well as esophagitis , respectively in terms of pain reduction and total or partial healing.

It is also estimated that omeprazole is in the first instance to treat Zollinger-Ellison syndrome , likewise in cases that are invulnerable to H2 antagonists, in the same way we have that omeprazole provides a great option in terms of total surgery or gastrectomy partial, as the case may be, respectively .

meta-analysis was also carried out determining people with duodenal or gastric ulcers, felt great relief or total improvement by using omeprazole at a dose of 20 mg once a day, as opposed to those who were relieved by using ranitidine. in doses of 150 mg, twice a day or 300 mg at night.

Omeprazole or pantoprazole which is better?

To treat gastritis or other problems, many unknowns arise today, since some of them are generated by stress or emotional problems, which without realizing it somatize in the stomach or towards other parts of the body. That is why going to the doctor is the best thing we should do, they as specialists will give their opinion and subsequent evaluation for our well-being through recommendations and the use of medications.

Both products are administered to combat heartburn problems, however they have some differences that are important to highlight:

In the case of omeprazole, it is a drug option that is used to combat esophagitis and gastritis, respectively, in addition to being a proton pump inhibitor, which is used to reduce the production of gastric acids in the body.

On the other hand we have pantoprazole which is a proton inhibitor. That is why many gastroenterologists trust this 40mg medicine to initiate a gastrointestinal ulcer healing procedure. That is why it is considered its use for gastritis because it is more intense.

The first week you notice the effective change to these gastric discomforts which lower their level to give way to the healing process of these from the 4th week after the treatment does not negatively affect mixed with other medications.

All treatments are useful and each one is suitable according to the pathology of each patient, both are very powerful and effective in it.

Which is better omeprazole or almax?

Medical specialists in the field determined that the consumption of omeprazole under their recommendations does not generate any health problems. Similarly, there are no studies that prove the blocking by omeprazole towards the reception of vitamins b12 in the body.

Symptoms such as heartburn are very common, there are more and more people affected by this situation, diet plays a very important role, it must be balanced low in sugar, fat, and carbohydrates that in excess negatively affect the body.

The drug almax together with omeprazole only have a common objective to relieve the stinging and burning presented in the esophagus by the incidence of gastric acids.

Almax acts as an antacid, which is effective for relief at the time of heartburn, unlike omeprazol, which requires a reasonable period of time to moderately control it. All of these need to be taken the right way to avoid health problems later on.

Omeprazole interactions

The consumption of Omeprazole can intervene the effect of the drugs that we name you:

Rifamycin, Clopidogrel, nelfinavir, antifungals such as ketoconazole, fluconazole, and itraconazole, mycophenolate, atazanavir, mofetil, mesalamine, indinavir, bisphosphonates, and phenytoin

On the other hand, Omeprazole has a positive effect on drugs such as:

  • Tacrolimos, methotrexate, escitalopram, amphetamines, carvedilol benzodiazepines (eg, diazepam), citalopram, cyclosporine, tacrolymes, dabigratan, and warfarin.
  • It is important that we name only a few because there are many, to which we always suggest you consult with your doctor.
  • It should be noted that Omeprazole does not alter the effectiveness of the contraceptive pill.

Omeprazole and veterinary uses

Omeprazole in dogs, what is the dose?

Omeprazole is also used to treat gastritis in domestic animals such as dogs and cats, acting as an antacid and antiulcer.

It must be administered orally, with food or alone. The tablets must not be crushed.

  • Helicobacter pilory infections: give ½ tablet every 10 kg of weight, 1 time per day. Good for at a dose of 0.5mg / kg. Mixed with Metronidazole and Amoxicillin or according to the vet.
  • Gastric Ulcer: give 1 tablet for every 10kg or 20kg of weight: once a day for 10 days and up to 30 days. This to the dose of 0.5-1mg / kg.
  • Gatrinoma: Zollinger-Ellison syndrome: give 1 tablet every 10 kg of weight, once a day for 10 days and up to 30 days. It corresponds to the dose of 1mg / kg.
  • Gastric ulcer insensitive to H2 blockers: give 1 tablet every 10 kg of weight, once a day for 10 days and up to 30 days. It corresponds to the dose of 1mg / kg.
  • Esophagitis: give 1 tablet every 5-10 kg of weight, once a day. It corresponds to the dose of 1-2 mg / kg.
  • Ulcers in felines: 1 tablet every 10kg of weight, 1 or 2 times a day for 10 days or according to the veterinarian. Worth at the dose of 1mg / kg.

It also disables the gastric acid mucus, directly hindering the proton pump H + / K + ATP handle in the parietal cell of the stomach, in this way it is avoiding the final transport of hydrogen ions towards the gastric lumen, in this sense it is preventing the formation hydrochloric acid chemistry.

It is important to mention that the efficiency of Omeprazole against Helicobacter bacteria, due to the hypochlorhydria that originates, is also due to its effect on the bacteria.

The statement about Nogastrol tablets with enteric-coated pellets defined the possibility of transferring gastric acidity while preserving its integrity until reaching the intestine, thus increasing the bioavailability of this drug as Omeprazole.

Long-term effects of omeprazole

Omeprazole is known as a treatment with a high level of safety, with a very low rate of serious adverse effects.

That is why we name you some of the most frequent adverse effects such as

  • Abdominal pain in 5%
  • Allergic skin reactions in 2%
  • Constipation 2%
  • Headache in 7%
  • Diarrhea in 4%
  • Flatulence in 3%
  • Nausea in 4%
  • Vomiting in 3%
  • Pneumonia in 1%
  • Cough in 1%
  • Dizziness in 2%
  • Low back pain in 1%

The most serious and strange side effects that are in only 0.1% of people:

  • Osteoporosis
  • Low blood magnesium or Hypomagnesemia
  • Interstitial Nephritis.
  • Atrophic gastritis.
  • Chronic kidney failure.
  • Diarrhea caused by the bacteria Clostridium difficile.
  • Liver Toxicity.

They are strange cases but, as we have already mentioned, their use for a long time increases the appearance of them , although it is contradictory since more and more people have started the use of omeprazole. It should be done in a moderate way.

Omeprazole contraindications

In general, the only existing contraindication to omeprazole, above corresponds to having some type of allergy with respect to drugs that is a type of proton pump inhibitors.

The absence of clinical studies on the effect of omeprazole in pregnancy, leads to the recommendation not to use it when it is in this stage.

Omeprazole SmPC

Molecular formula:

Corresponds to C17H19N3O3S

Molecular weight:

Its weight is 345.4

Physical-Chemical Data:

It is a white or almost white powder, almost transparent in tone. With little solubility in water , however it is soluble in methylene chloride , as well as it is quite soluble in 96% ethanol and methanol as well. In the same way, it dissolves in alkaline hydroxide solutions.

Melting point:

It is represented at 156 ° C.

Properties and uses:

Omeprazole is clearly considered to be a proton pump inhibitor. Since it clearly prevents the secretion of gastric acid through an unbreakable blockage on the enzymatic process of the hydrogen-potassium adenosine triphosphatase, that is, the proton pump, of the gastric parietal cell. It is also handled in methods in which it is very useful to inhibit gastric acid secretion, such as gastroesophageal reflux disease, aspiration syndromes, as well as dyspepsia, peptic ulcer and Zollinger-Ellison syndrome. respectively.


Peptic ulcer : it is 20 mg per day, or 40 mg in severe cases, for 4 weeks in relation to duodenal ulcers and for 8 weeks in gastric ulcers. Therefore it is impossible to extend them to longer periods,

Acid aspiration during general anesthesia: the initial dose consists of 40mg the night before and 40mg, more in 2-6 h before surgery.

Dyspepsia: it is 10-20 mg a day orally for 2 or 4 weeks.

Zollinger-Ellison Syndrome: for this, an initial dose of 60 mg per day is recommended, in the same way, doses of 20 – 120 mg per day can be used.

Gastroesophageal reflux disease: it is 20 – 40 mg per day, for a period of 4 to 8 weeks; maintenance treatment can be continued through 20 mg per day.

Helicobacter pylori Eradication: consists of 20 to 40 mg per day mixed with antibiotics.

Ulcers from NSAIDs: it is 20 mg / day.

For doses higher than 80 mg it is better to divide in two doses. In cases like these, treatment is preserved to stop the disease or keep it under control.

Side effects:

An increase in liver enzymes, jaundice and hepatic encephalopathy, as well as in isolated cases of hepatitis have been represented. In the same way, they are exceptionally established are: alopecia, paresthesias, hyponatremia, sweating, blurred vision , taste disturbances, stomatitis, peripheral edema, general malaise, hematic alterations and interstitial nephritis.

On the other hand, the repetitively described adverse effects such as diarrhea, headache, and rashes.

There are also the effects on the CNS, which are based on occasional insomnia, vertigo, drowsiness , in that same order are reversible confusion, depression, agitation, and hallucinations in seriously ill patients.

Other common effects are : dizziness, itching, fatigue, vomiting, constipation, abdominal pain, nausea, flatulence, arthralgias and myalgias, as well as hives and xerostomia.

There are certain isolated cases of bullous eruption, angioedema, photosensitivity, erythema multiforme, and anaphylaxis.


It is important to know that the elimination of phenytoin, diazepam, and warfarin can be extended. With regard to lowering the levels of gastric acidity, which is caused by omeprazole that affects the absorption of other medications.

Omeprazole is also metabolized for the liver, therefore it is considerable to compress the dose in case of liver failure.

It is very important to take into account before prescribing omeprazole, towards patients affected with gastric ulcers, which has to rule out cancer, because it could confuse certain symptoms related to other diseases and extend its diagnosis, without knowing it.

This drug can inhibit the cytochrome P450 procedure, considerably altering the metabolism towards other metabolized drugs with respect to these enzymes.


Omeprazole must inhibit the cytochrome P450 process , as well as to alter the metabolism of other drugs metabolized by these enzymes. In the same way, the elimination of phenytoin from diazepam and warfarin can be extended. It also influences the effectiveness of ketoconazole and possibly deitraconazole and lowers its level of effectiveness, in the same way its absorption is due to gastric acid pH.


Acofarma Oral Vanilla Essence or omeprazole preparations may turn yellow to brown over time.


Conservation is carried out in properly closed containers . Likewise, it must be protected from direct light, and kept refrigerated between 2 – 8ºC. Formulation examples:

Omeprazole suspension 2 mg / ml Omeprazole with a base of 0.2%, Sodium bicarbonate of 8.4% Xanthan gum Aqueous solution at 1% 50 ml, the Essence either strawberry, cherry, or red fruits, 0.1 -0.3% Sodium Saccharin 0.1-0.2% Purified water qspcsp 100 ml respectively.

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Kathie Sand always saw the world of beauty as the terrain on which to build her professional career, a goal that was clear to her when she was only 15 years old. Her great concern to expand knowledge led her to settle in Paris where she studied hand in hand with the best beauty professionals and with the most advanced techniques for skin care.

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